Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood

Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood

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The use of cannabidiol (CBD) for animal species is an area of growing interest, for example for its anti-inflammatory and immuno-modulating properties, even though all of its biological effects are still not fully understood, especially in veterinary medicine.Therefore, the aim of this study was to investigate the anti-inflammatory and immuno-modulating properties of CBD for the first time directly in canine inflammatory response.We used an ex vivo model of LPS-stimulated whole dog blood.We stimulated the whole blood from offworld drum pads healthy dogs with LPS 100 ng/mL for 24 h in the presence or not of CBD 50 and 100 μg/mL.We observed a reduction in IL-6 and TNF-α production from the group treated with CBD, but non-altered acure face lotion IL-10 levels.

Moreover, we also observed from the CBD-treated group a reduction in Nf-κB and COX-2 expression.In conclusion, we demonstrated for the first time the anti-inflammatory and immuno-modulating properties of CBD directly in dogs’ immune cells, using a canine ex vivo inflammatory model.The results obtained from these studies encourage further studies to better understand the possible therapeutic role of CBD in veterinary medicine.